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desvenlafaxine will improve the level or effect of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Caution/Check. Desvenlafaxine inhibits CYP2D6; with bigger desvenlafaxine doses (ie, 400 mg) minimize the CYP2D6 substrate dose by nearly 50%; no dosage adjustment wanted with desvenlafaxine doses seven consecutive times quickly prior to us